Protective effect of leaf extract of Ficus carica L. against carbon tetrachloride-induced hepatic toxicity in mice and HepG2 cell line

Purpose: To determine the in vivo and vitro hepatoprotective effects of Ficus carica.Methods: The methanol leaf extract carica L was further fractionated into n-hexane, ethyl acetate aqueous fractions. For study, male albino mice were divided twelve groups. Hepatotoxicity induced using carbon tetrachloride (CCl4). F. its fractions administered at doses 200 400 mg/kg. Silymarin used as standardhepatoprotective drug. protective determined via assay biochemical parameters antioxidant enzymes liver. histopathology liver also studied. Moreover, effect against CCl4-induced damage HepG2 cell line.Results: There significant increases serum levels biomarkers CCl4-treated group, whereas treatments with plant significantly reduced these (p < 0.05). In addition, results from revealed evidence through reversal decreases activities enzymes.Conclusion: These indicate that L. exert dose-dependent vitro.
 Keywords: carica, Hepatoprotection, Carbon tetrachloride, Liver